DREAM Is a Critical Transcriptional Repressor for Pain Modulation
نویسندگان
چکیده
Control and treatment of chronic pain remain major clinical challenges. Progress may be facilitated by a greater understanding of the mechanisms underlying pain processing. Here we show that the calcium-sensing protein DREAM is a transcriptional repressor involved in modulating pain. dream(-/-) mice displayed markedly reduced responses in models of acute thermal, mechanical, and visceral pain. dream(-/-) mice also exhibited reduced pain behaviors in models of chronic neuropathic and inflammatory pain. However, dream(-/-) mice showed no major defects in motor function or learning and memory. Mice lacking DREAM had elevated levels of prodynorphin mRNA and dynorphin A peptides in the spinal cord, and the reduction of pain behaviors in dream(-/-) mice was mediated through dynorphin-selective kappa (kappa)-opiate receptors. Thus, DREAM appears to be a critical transcriptional repressor in pain processing.
منابع مشابه
Title of dissertation: STRUCTURAL CHARACTERIZATION OF METAL AND DNA BINDING TO DREAM PROTEIN, A CALCIUM SENSING TRANSCRIPTIONAL REPRESSOR IN PAIN MODULATION
Title of dissertation: STRUCTURAL CHARACTERIZATION OF METAL AND DNA BINDING TO DREAM PROTEIN, A CALCIUM SENSING TRANSCRIPTIONAL REPRESSOR IN PAIN MODULATION Aswani Kumar Valiveti, Doctor of Philosophy, 2006 Dissertation directed by: Dr. James. B. Ames Center for Advanced Research in Biotechnology DREAM (Downstream Regulatory Element Antagonistic Modulator) is the first reported calcium binding ...
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ورودعنوان ژورنال:
- Cell
دوره 108 شماره
صفحات -
تاریخ انتشار 2002